Dexilant vs. other PPIs

Dexilant vs. other PPIs

November 5th, 2018 | Clinical ConnectionsNews

Dexilant: Dexilant is one of several available proton pump inhibitors (PPIs); while there are several PPIs to pick from, there is currently no RCT evidence to suggest that any PPI is preferred over another for GERD, nocturnal reflux, PUD-related symptoms, or endoscopically-confirmed healing of esophagitis. Dexilant, available as brand-name only, is 28 times more expensive than other available and effective generic PPIs. Dexilant is also tier 3 on many insurance plans, representing potential higher cost share for patients and often requires additional paperwork to be completed for coverage. See below for several counter-detailing points related to common Dexilant marketing messages or “selling points”:

Takeaway message: Dexilant is significantly more expensive than other available PPIs and does not offer a clinical advantage supported by the literature. Consider utilizing alternative, less expensive options (generic pantoprazole, omeprazole, or esomeprazole) for patients who need PPI treatment. For patients with nocturnal reflux an AM dose of a generic PPI and PM dose of an H2RA (ranitidine or famotidine) would be a cost-effective alternative regimen to Dexilant.