Home / Pharmacy Pearls- Antidepressant Treatment in Primary Care: Initiation and Management of Inadequate Response

Pharmacy Pearls- Antidepressant Treatment in Primary Care: Initiation and Management of Inadequate Response

Aug 12, 2026 | Behavioral Health, Pharmacy, Pharmacy Pearls

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This two-page edition of Pharmacy Pearls outlines a stepwise approach to depression treatment in primary care, including selecting antidepressants based on symptoms, monitoring response, and adjusting treatment when appropriate. It emphasizes optimizing treatment before switching medications, using augmentation strategies when appropriate, and referring to psychiatry for more complex or treatment-resistant cases.

As always, we welcome any questions or feedback you may have. Just email the Pharmacy Team.

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